Our research focuses on the intersection of genetics, ecology, and technology to address real-world challenges in food security, animal health, and disease vector control. We employ cutting-edge techniques, including multi-omics, genomics, and artificial intelligence, to comprehend the intricate biological systems of domesticated animals and insects.
Broiler Breeder Fertility
Our lab is dedicated to solving the complex issue of declining fertility in broiler breeders. This research is crucial for ensuring the sustainable production of poultry to meet global food demand. We’re using a multi-omics approach—integrating data from genomics, transcriptomics, and metabolomics—to uncover the genetic and physiological factors behind this decline. By applying deep learning and AI, we analyze extensive datasets and high-resolution imaging to identify key markers and traits associated with reproductive performance, paving the way for targeted breeding and management strategies.
Gut-Brain-Immune Signaling in Chickens
We study the intricate bidirectional communication between the gut, brain, and immune system in chickens. This research uses a challenge model to induce physiological responses and then precisely measure the downstream effects. By employing cutting-edge techniques like single-cell RNA sequencing (scRNAseq), we can analyze gene expression at the cellular level, providing an unprecedented view of how different cell types in the gut and brain communicate. We also use peptidomics to identify and quantify the small protein molecules that act as messengers in this complex signaling network. This work helps us better understand how the gut microbiome and the immune system influence behavior, stress, and overall health in poultry.
Mosquito Vector Biology
Our lab is dedicated to understanding the behavioral plasticity of malaria vectors, with a specific focus on the shift toward outdoor feeding behaviors. This adaptation poses a significant challenge to traditional vector control methods. We investigate the gut-brain signaling pathways in mosquitoes, incorporating microbiome and transcriptomics data to uncover the molecular mechanisms that drive these behavioral changes. By deciphering how the mosquito’s gut microbiome influences its brain and feeding habits, we aim to develop new, targeted strategies to combat malaria transmission.
Insects as Vectors of Antimicrobial Resistance
We are at the forefront of research on the role of insects as vectors of antimicrobial resistance (AMR) in livestock environments. Using a combination of field sampling, metagenomics, and AI approaches, we identify and track the spread of antibiotic-resistant genes and bacteria carried by insects. This work is crucial for understanding how AMR spreads beyond clinical settings and for developing new biosecurity protocols to protect both animal and human health.